Makale detayı · 2018
Synthesis and anticancer (MCF-7, PC-3) activities of new 2-hydroxy- 2,2-bis(4-substitutedphenyl)-N'-[(1E)-(3/4- substitutedphenyl)methylene]-acetohydrazides
- Yıl
- 2018
- ISSN
1307-6175- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
İngilizce (OpenAlex)
A series of five -CH3, -NO2, -OCH3 and -Cl substituted 2-hydroxy-2,2-bis(4-phenyl)-N'-[(1E)-(3/4phenyl)methylene]acetohydrazide (1a-1e) was synthesized by the reaction of 2-hydroxy-2,2-diphenylacetohydrazide with substituted aromatic aldehydes to give intermediate Schiff bases. Structures of the synthesized compounds were characterized using NMR (1D; 1 H, 13 C/APT and 2D 1 H-1 H COSY, and NOESY), FT-IR, UV, LC-MS/MS spectral data and elemental analysis. The geometry of compounds 1a-1e were determined to be "E" by NOESY. All the tested compounds showed cytotoxic activity on MCF-7 and PC-3 cell line at highest experimental concentration (100 M). Compounds 1b (18.24 7.62 M) and 1e (7.62 1.85 M) have strong anti-proliferative activity on MCF-7 cell line, while compound 1b (45.81 1.10 M) has the strongest activity on PC-3 cell line.
Konular
- Synthesis and biological activity
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
Birincil konu Synthesis and biological activity