TGF-β and Wnt Pathways Underlying the Pathophysiology of Degenerative Mitral Valve Regurgitation

İngilizce (OpenAlex)

Objectives: In aging society, hospitalizations and mitral valve surgeries are becoming more common due to progressive mitral valve diseases that ultimately lead to heart failure. In developing countries, degenerative mitral valve regurgitation (DMVR) is the leading cause of mitral regurgitation requiring surgical treatment. Nevertheless, a more profound understanding of the underlying pathological processes via a molecular biology approach could improve clinical management. In this study, bioinformatic analyses were performed to elucidate the underlying pathophysiological molecular mechanisms using transcriptome data of atrial tissues from patients with DMVR.