Makale detayı · 2012
Blood compatibility of polymers derived from natural materials
- Yıl
- 2012
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Journal of Bioactive and Compatible Polymers
- Katalog eşleşmesi (ISSN) Journal of Bioactive and Compatible Polymers
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
Several polymers derived from natural materials are effective for tissue engineering or drug delivery applications, due to specific properties, such as biocompatibility, biodegradability, and structural activity. Their blood compatibility needs to be carefully evaluated to avoid thrombosis and other material-related adverse events in the hematic environment. We compared the surface properties and blood compatibility of protein and polysaccharide polymers, including fibroin, gelatin, and chitosan. Both fibroin and chitosan showed good hemocompatibility, with low platelet adhesion and spreading. Chitosan induced strong interactions with plasma proteins, especially with albumin. It was hypothesized that surface passivation by albumin inhibited the adsorption of other procoagulant and proadhesive proteins on chitosan and fibroin films, which limited platelet spreading. However, the significant and rapid polymer swelling encouraged protein entrapment within the soft, gelatin films, inducing higher platelet adhesion and activation. Thrombin generation assay confirmed the higher blood compatibility of chitosan and fibroin with regard to clotting.
Konular
Atıflar
OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.
31 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 6 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- Immobilization of heparin on chitosan grafted polyurethane films to enhance anti adhesive and antibacterial properties 2016
- Heparin/Chitosan/Alginate Complex Scaffolds as Wound Dressings: Characterization and Antibacterial Study Against Staphylococcus epidermidis 2015
- Heparin/Chitosan/Alginate Complex Scaffolds as Wound Dressings: Characterization and Antibacterial Study Against Staphylococcus epidermidis 2015
- Heparin Chitosan Alginate Complex Scaffolds as Wound Dressings Characterization and Antibacterial Study Against I Staphylococcus epidermidis I 2015