Inflammation in Chronic Psychiatric Patients: Neutrophil/Lymphocyte Ratios, Platelet/Lymphocyte Ratios, and Mean Platelet Volume

OpenAlex İngilizce

Objective: The aim of this study was to examine the Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratios (PLR), and Mean Platelet Volume (MPV), red blood cell distribution width (RDW) and leukocyte cell levels of inpatients with mental illness by comparing them with each other and healthy controls. Materials and Methods: A total of 600 people were included in our study, 500 of whom were taken as the patient and 100 as the control group. The diagnosis of patients according to DSM-5-Criteria were 34.8% Schizophrenia, 21% had Generalized-Anxiety-Disorder, 14.4% had Bipolar-Affective-Disorder, 14% had Major-Depressive-Disorder, 7.2% had Adjustment-Disorder, 4.2% had Schizoaffective-Disorder, 3.6% had other psychiatric illnesses. Results: It was seen that hemoglobin, platelet, monocyte, blood platelet distribution (PCT), percentage account of RDW (RDW-CV) did not have statistically significant differences between groups (p values were 0.082, 0.214, 0.526, 0.082, 0.771, respectively). The lymphocyte, eosinophil, basophil, MPV, standard deviation of RDW (RDW-SD) were higher compared with healthy controls (p values were 0.002, 0.003, <0.001, <0.001, 0.003, 0.003, respectively). NLR and PLR were low in the patient group compared to healthy controls (p<0.001). Conclusion: It was found that some of the inflammation parameters of chronic with mental illness were different from those of healthy controls. However, further prospective studies are needed to better reveal the relationship between inflammatory parameters and mental illnesses..