Anti-Fibrotic and Regenerative Potential of Mesenchymal Stem Cell-Derived Exosomes in Cisplatin-Induced Kidney Injury

OpenAlex İngilizce

Cisplatin is a widely used chemotherapeutic agent with potent antitumor activity; however, its nephrotoxicity limits clinical use, affecting 30–40% of treated patients. This study aimed to investigate the effects of mesenchymal stem cell-derived exosomes on cisplatin-induced nephrotoxicity and fibrosis in rat kidney tissue. Rats were divided into Control, Cis, Exo, and Cis+Exo groups. Nephrotoxicity was induced by a single dose Cis. Exosomes were isolated using a commercial kit and characterized by nanoparticle tracking analysis. Histopathological evaluations were performed Hematoxylin&Eosin and Periodic Acid-Schiff. Fibrosis markers were assessed by immunohistochemistry. Statistical analyses were conducted using one-way ANOVA and Kruskal-Wallis tests with Bonferroni and Dunn’s post-hoc tests, considering p