Makale detayı · 2008
Carbapenem hydrolyzing oxacillinase OXA 48 persists in Klebsiella pneumoniae in Istanbul Turkey
Dergi
Chemotherapy- Yıl
- 2008
- Dış bağlantı
- https://dx.doi.org/DOI:10.1159/000118661
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Chemotherapy
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
BACKGROUND: Two OXA-48-producing Klebsiella pneumoniae isolates (KP-4936 and KP-154488) were analyzed. METHOD: Minimum inhibitory concentrations were determined using agar dilution and E-test, beta-lactamase production by phenotypic tests (E-test MBL and ESBL, isoelectric focusing, and bioassay) and molecular methods (PCR, RAPD-PCR, sequencing, plasmid analysis, and conjugation). RESULTS: Isolates were resistant to all beta-lactams, including carbapenems. PCR and sequencing identified bla(OXA-48) in both isolates and the transconjugant. KP-4936 harbored bla(TEM-1) (pI 5.4) and bla(CTX-M-15) genes (pI 8.6), while KP-154488 was positive for bla(TEM-1) (pI 5.4), bla(CTX-M-15) (pI 8.9), and bla(SHV2a) (pI 7.6), in addition. The enzyme with a pI of 7.2 hydrolyzed imipenem according to a bioassay result. Plasmids (70 and 140 kb) from KP-4936 were transferred by conjugation. RAPD-PCR found no clonal relationship between the two strains. CONCLUSION: Carbapenem resistance may spread among Enterobacteriaceae via the transferable enzyme OXA-48.
Konular
Atıflar
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91 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 77 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Epidemiology of antimicrobial resistance in bloodstream infections 2016
- Spread of OXA 48 Encoding Plasmid in Turkey and Beyond 2010
- Spread of OXA-48-Encoding Plasmid in Turkey and Beyond 2010
- Spread of OXA 48 Positive Carbapenem Resistant Klebsiella pneumoniae Isolates in Istanbul Turkey 2008
- In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae 2012
- In vitro activity of avibactam NXL104 in combination with lactams against Gram negative bacteria including OXA 48 lactamase producing Klebsiella pneumoniae 2012
- Blood stream infections due to OXA 48 like carbapenemase producing Enterobacteriaceae treatment and survival 2014
- Blood stream infections due to OXA 48 like carbapenemase producing Enterobacteriaceae treatment and survival 2014
- Blood stream infections due to OXA-48-like carbapenemase-producing Enterobacteriaceae: treatment and survival 2014
- Blood stream infections due to OXA-48-like carbapenemase-producing Enterobacteriaceae: treatment and survival 2014