Makale detayı · 2019
Gundelia rosea seed: Evaluation of biopharmaceutical potential and bioactive composition
- Yıl
- 2019
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı South African Journal of Botany
- Katalog eşleşmesi (ISSN) South African Journal of Botany
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
Ethyl acetate (EA), methanol (MeOH), and aqueous extracts of aerial parts of Anthemis tinctoria var. pallida (ATP) and A. cretica subsp. tenuiloba (ACT) were investigated for their phenol and flavonoid content, antioxidant, and key enzyme inhibitory potentials. All extracts displayed antiradical effects, with MeOH and aqueous extracts being a superior source of antioxidants. On the other hand, EA and MeOH extracts were potent against AChE and BChE. Enzyme inhibitory effects against tyrosinase and α-glucosidase were observed, as well. We also studied Anthemis extracts in an ex vivo experimental neurotoxicity paradigm. We assayed extract influence on oxidative stress and neurotransmission biomarkers, including lactate dehydrogenase (LDH) and serotonin (5-HT), in isolated rat cortex challenged with K+ 60 mM Krebs-Ringer buffer (excitotoxicity stimulus). An untargeted proteomic analysis was finally performed in order to explore the putative mechanism in the brain. The pharmacological study highlighted the capability of ACT water extract to blunt K+ 60 mM increase in LDH level and 5-HT turnover, and restore physiological activity of specific proteins involved in neuron morphology and neurotransmission, including NEFMs, VAMP-2, and PKCγ, thus further supporting the neuroprotective role of ACT water extract.
Konular
Atıflar
OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.
37 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 41 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Tanacetum vulgare L. (Tansy) as an effective bioresource with promising pharmacological effects from natural arsenal 2021
- Integrated phytochemistry, bio-functional potential and multivariate analysis of Tanacetum macrophyllum (Waldst. & Kit.) Sch.Bip. and Telekia speciosa (Schreb.) Baumg. (Asteraceae) 2020
- Multidirectional Pharma-Toxicological Study on Harpagophytum procumbens DC. ex Meisn.: An IBD-Focused Investigation 2020
- Chemical composition and biological properties of Synedrella nodiflora (L.) Gaertn: A comparative investigation of different extraction methods 2020
- The Association of Tanacetum parthenium and Salix alba Extracts Reduces Cortex Serotonin Turnover, in an Ex Vivo Experimental Model of Migraine 2022
- Determination of phenolics composition, antioxidant activity, and therapeutic potential of Golden marguerite (Cota tinctoria) 2021
- Extraction Technique Impacts on Phenolic Profile, AntioxidantCapacity, and Enzyme Inhibition by Anthemis pseudocotula 2025
- Extraction Technique Impacts on Phenolic Profile, Antioxidant Capacity, and Enzyme Inhibition by Anthemis pseudocotula 2025
- Extraction Technique Impacts on Phenolic Profile, Antioxidant Capacity, and Enzyme Inhibition by Anthemis pseudocotula 2025
- Exploring hidden natural resources for bioactive compounds: Focused chemical and biological studies on some Anthemis species 2025