Assessment of the Association Between Complete Blood Cell Parameters, Levels of Vitamin B12 and Folate, Decreased Iron Storage and Recurrent Vasovagal Syncope Episodes

OpenAlex İngilizce

Objective: To evaluate the relationship between recurrent vasovagal syncope (VVS) and complete blood cell parameters, serum levels of ferritin, vitamin B 12 , and folate. Materials and Methods: This retrospective study included patients with recurrent VVS and healthy controls. Children and adolescents presenting with at least two VVS episodes were included. Exclusion criteria were as follows; having an electrocardiogram abnormality, patients without an evident trigger before fainting, having an infection, having a history of chronic disease, and taking any medications or vitamin supplements, including folate, vitamin B 12 , and iron. Results: A total of 44 patients and 66 healthy controls were included. There were no significant differences between the groups in terms of age and gender. Mean corpuscular hemoglobin concentration (MCHC) (p=0.014), mean platelet volume (MPV) (p=0.020), and levels of ferritin (p<0.0001) were significantly lower in the patient group. No significant differences were found between the groups with respect to other laboratory parameters. Binary logistic regression analysis showed that every 1-unit decrease in serum ferritin constitutes a 0.972 [95% confidence interval (CI)= 0.954-0.990] fold risk. Also, every 1-unit decrease in MPV constitutes a 0.453 (95% CI=0.275-0.745) fold risk of VVS. Conclusion: This study showed lower levels of serum ferritin, smaller platelet sizes, and lower levels of MCHC. Additionally, smaller platelet sizes and lower levels of ferritin were independent risk factors.