Six-minute walk test to assess muscular fatigability and mobility in children with congenital myasthenic syndrome: a pilot study

OpenAlex İngilizce

OBJECTIVE: The aims of this study were to determine whether the six-minute walk test predicts muscular fatigability in ambulant children with congenital myasthenic syndrome and to examine the relationship between the six-minute walk test and mobility tests. METHODS: Eight children (four girls and four boys) with congenital myasthenic syndrome (mean age: 11.75±3.54 years) were included. Five children had COLQ variants. The distance of each minute for the six-minute walk test was determined to evaluate fatigability. The mobility tests included the 10-m walk/run test, rising from the floor, and climbing up and down four stairs. RESULTS: The mean six-minute walk test distance was 463.38±132.59 m. There was no difference between the first and last minute, between the first and last two minutes, and between any of the minutes during the six-minute walk test (p>0.05). The mean times for performing the 10-m walk/run test, rising from the floor, and climbing up and down four stairs were 8.59±3.36, 6.38±4.49, 4.38±5.07, and 3.35±3.69 s, respectively. The strong correlations were determined between six-minute walk test and all the mobility tests, except for climbing down four stairs (p< 0.05, rs=-0.72 to -0.83). CONCLUSION: The six-minute walk test did not provide sufficient evidence to predict muscular fatigability. However, this preliminary study suggested that the six-minute walk test may be used by clinicians and researchers to assess mobility in congenital myasthenic syndrome.